Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis's newest and most modern Holiday Inn Express hotel is nestled within a growing development at the intersection of Butler Hill Road and I-55, just one mile south of I-270/255, with access to everything St. Louis offers. Located just 14 miles south of downtown St. Louis at exit 195 off I-55, business travelers will benefit from our central location with easy on/off access to I-55, connecting to different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center and Mercy Health. We are also minutes from MetLife, Anheuser-Busch, Cigna, and the National Cemetery Administration. Our non-smoking Holiday Inn Express & Suites St. Louis I-55 hotel offers convenient access for guests visiting Busch Stadium, the Gateway Arch, Grant's Farm, the Magic House, the St. Louis Science Center, the St. Louis Zoo, Forest Park, River City Casino, and much more! Hotel guests can enjoy an array of amenities, including suites, an indoor pool, a Suite Shop, two meeting rooms, a complimentary Express Start breakfast, complimentary high-speed wired and wireless internet, a comfortable Great Room with an outdoor patio, and warm cookies and milk served nightly. Experience genuine Midwestern hospitality at our South St. Louis location.