Now Open! Red Roof Inn Wytheville welcomes you with warm hospitality, clean and comfortable accommodations, and a location that makes travel easy. Conveniently situated just off Highway 11 with quick access to I-77 and US-52, our hotel is ideal for road trippers, families, business travelers, and outdoor adventurers alike. Whether you're visiting nearby Blacksburg, catching a flight at Mountain Empire Airport, or exploring local favorites like Ager Park, Rocky Hollow Farm, or the scenic Blue Ridge Parkway. Guests at Red Roof Inn Wytheville enjoy a variety of thoughtful amenities. Stay connected with free Wi-Fi, unwind with our expanded cable package featuring HBO, and enjoy complimentary coffee in the lobby throughout the day. All guest rooms feature a microwave, mini-refrigerator, and modern furnishings, with select rooms offering kitchenettes for extended stays.